Polysaccharides from Passion Fruit Peels: From an Agroindustrial By-Product to a Viable Option for 5-FU-Induced Intestinal Damage

Gastrointestinal mucositis is a serious and dose-limiting toxic side effect of oncologic treatment. Interruption cancer treatment due to gastrointestinal leads significant decrease in cure rates consequently the deterioration patient’s quality life. Natural polysaccharides show variety beneficial effects, including gastroprotective effect. Treatment with soluble dietary fiber (SDF) from yellow passion fruit (Passiflora edulis) biomass residues protected gastric intestinal mucosa models injury. In this study, we investigated protective therapeutic SDF on 5-FU-induced male female mice. Oral animals did not prevent weight loss but reduced disease activity index preserved normal function by alleviating diarrhea altered transit. length colon histological damage caused 5-FU. significantly restored oxidative stress inflammation intestine enlargement swelling spleen induced conclusion, may be promising adjuvant strategy for prevention